Mammalian Metallothioneins: Properties and Functions

Metallomics. 2012 Aug;4(8):739-50. doi: 10.1039/c2mt20081c. Epub 2012 Jul 13.

Abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antineoplastic Agents / pharmacology
  • Apoptosis
  • Cadmium / metabolism
  • Cell Proliferation
  • Drug Resistance, Neoplasm
  • Free Radicals / metabolism
  • Glutathione / metabolism
  • Humans
  • Metallothionein / chemistry*
  • Metallothionein / metabolism*
  • Metals / metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Neoplasms / drug therapy

Substances

  • Antineoplastic Agents
  • Free Radicals
  • Metals
  • Cadmium
  • Metallothionein
  • Glutathione