Podocyte ACE2 protects against diabetic nephropathy

Kidney Int. 2012 Aug;82(3):255-6. doi: 10.1038/ki.2012.127.


As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzyme 2 (ACE2), which can decrease angiotensin II levels by generation of angiotensin-(1-7). Nadarajah et al. now show that increased podocyte ACE2 activity can attenuate the development of diabetic nephropathy.

Publication types

  • Comment

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Diabetic Nephropathies / enzymology*
  • Diabetic Nephropathies / genetics*
  • Humans
  • Male
  • Peptidyl-Dipeptidase A / genetics*
  • Peptidyl-Dipeptidase A / metabolism*
  • Podocytes / enzymology*


  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2