A feud that wasn't: acetylcholine evokes dopamine release in the striatum

Neuron. 2012 Jul 12;75(1):1-3. doi: 10.1016/j.neuron.2012.06.028.


In this issue of Neuron, Threlfell et al. (2012) report that synchronous activation of cholinergic interneurons evokes striatal dopamine release by activating presynaptic nicotinic acetylcholine receptors. These findings call for a fundamental reevaluation of the long-standing view that dopamine and acetylcholine "feud" over control of striatal circuitry.

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