Effects of standardized phytoestrogen on Taiwanese menopausal women

Taiwan J Obstet Gynecol. 2012 Jun;51(2):229-35. doi: 10.1016/j.tjog.2012.04.011.


Objective: To investigate the effects of standardized soy extract on climacteric symptoms, lipid profiles, bone markers, and serum isoflavone concentration in healthy Taiwanese postmenopausal women.

Materials and methods: A multicenter, open-labeled, randomized, prospective, comparative study design was used. A total of 130 outpatients who had undergone natural menopause were randomly administered either 70 mg or 35 mg soy extract daily for 24 weeks.

Results: The evidence suggests that the soy extract treatment that was administered to both groups for 1 month could help reduce climacteric scores (reductions of 19.66% [p<0.01] and 18.85% [p<0.01] in the 35 mg and 70 mg groups compared with baseline, respectively), and the efficacy was more potent after 6 months of treatment. Soy isoflavone significantly reduced the total cholesterol (reductions of 4.50% [p<0.01] and 3.06% [p<0.05] in the 35 mg and 70 mg groups, respectively) and low density lipoprotein cholesterol levels (reductions of 4.67% [p<0.05] and 5.09% [p<0.05] in the 35 mg and 70 mg groups, respectively) in patients with total cholesterol > 200 mg/dL after 6 months of treatment. In patients with high bone turnover (urinary deoxypyridinoline/creatinine > 7.4 nM/mM), soy extract treatment reduced the deoxypyridinoline/creatinine level by 10.53% (p<0.05) and 11.58% (p<0.05) in the 35 mg and 70 mg groups, respectively. Serum levels of isoflavone increased in both groups after 6 months of treatment.

Conclusion: Soy extract is highly efficacious at relieving menopausal symptoms and demonstrates a positive effect on the cardiovascular system and skeleton.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Amino Acids / blood
  • Amino Acids / drug effects
  • Analysis of Variance
  • Cholesterol / blood*
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / drug effects
  • Creatinine / blood
  • Female
  • Genistein / blood
  • Hot Flashes / drug therapy
  • Humans
  • Isoflavones / blood
  • Middle Aged
  • Phytoestrogens / pharmacology*
  • Phytoestrogens / therapeutic use*
  • Postmenopause / blood
  • Postmenopause / drug effects*
  • Severity of Illness Index
  • Soybeans


  • Amino Acids
  • Cholesterol, LDL
  • Isoflavones
  • Phytoestrogens
  • daidzein
  • deoxypyridinoline
  • Cholesterol
  • Creatinine
  • Genistein