Role of testosterone in managing advanced prostate cancer

Urology. 2012 Oct;80(4):754-62. doi: 10.1016/j.urology.2012.05.006. Epub 2012 Jul 13.


Androgen deprivation therapy is frequently used to treat patients with advanced prostate cancer. New therapies for metastatic castration-resistant prostate cancer have drawn increased attention to serum and intratumoral testosterone levels. The present review examines the role of testosterone in prostate cancer progression, discusses the nuances and potential pitfalls in measuring serum testosterone using available assays, and summarizes current data relevant to the arguments for and against achieving and maintaining the lowest possible testosterone levels during androgen deprivation therapy, including the adverse effects of such treatment. Incorporating this information, we have made recommendations incorporating testosterone evaluation and its effect on the clinical decision-making process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Androgen Antagonists / adverse effects
  • Androgen Antagonists / therapeutic use*
  • Blood Chemical Analysis
  • Disease Progression
  • Gonadotropin-Releasing Hormone / agonists*
  • Humans
  • Male
  • Practice Guidelines as Topic
  • Prostatic Neoplasms / blood*
  • Prostatic Neoplasms / drug therapy*
  • Testosterone / antagonists & inhibitors
  • Testosterone / blood*


  • Androgen Antagonists
  • Gonadotropin-Releasing Hormone
  • Testosterone