Review of miR-200b and cancer chemosensitivity

Biomed Pharmacother. 2012 Sep;66(6):397-402. doi: 10.1016/j.biopha.2012.06.002. Epub 2012 Jun 29.

Abstract

Chemoresistance remains a major obstacle to successful cancer treatment and leads to poor prognosis of the patients, yet the underlying mechanisms have not been fully understood. MicroRNAs (miRNAs) are non-coding small RNAs of 19-22 nucleotides which could negatively regulate gene expressions mainly through 3'-untranslated region (3'UTR) binding of target mRNAs. MiR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) is a cluster of miRNAs highly correlated with epithelial-mesenchymal transition (EMT), wherein miR-200b is identified as a critical regulator of tumor invasion, metastasis, and chemosensitivity. Recent advances of miR-200b dysregulation in tumor chemoresistance were summarized. Possible mechanisms and reversion strategies were also addressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use
  • Combined Modality Therapy
  • Drug Resistance, Neoplasm*
  • Epithelial-Mesenchymal Transition
  • Gene Expression Regulation, Neoplastic
  • Gene Transfer Techniques*
  • Humans
  • MicroRNAs / metabolism
  • MicroRNAs / therapeutic use*
  • Neoplasms / drug therapy
  • Neoplasms / therapy*
  • Neoplastic Stem Cells / drug effects
  • Neoplastic Stem Cells / metabolism

Substances

  • Antineoplastic Agents
  • MIRN200 microRNA, human
  • MicroRNAs