Churg-Strauss Syndrome: an evolving paradigm

Autoimmun Rev. 2012 Dec;12(2):235-40. doi: 10.1016/j.autrev.2012.07.009. Epub 2012 Jul 13.

Abstract

The Churg-Strauss Syndrome is an ANCA-associated vasculitis, an inflammatory multisystem disease with preference to the respiratory tract. Peripheral and tissue eosinophilia are the pathological hallmarks of this condition. The etiopathogenesis is unknown but some cytokines appear to play a central role and could be targets for new therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Antineutrophil Cytoplasmic / immunology
  • Asthma / complications
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Cell Communication
  • Chemokines, CC / immunology
  • Chemokines, CC / metabolism
  • Churg-Strauss Syndrome / complications
  • Churg-Strauss Syndrome / etiology*
  • Eosinophils / immunology
  • Eosinophils / metabolism
  • Humans
  • Th17 Cells / immunology
  • Th17 Cells / metabolism
  • Th2 Cells / immunology
  • Th2 Cells / metabolism

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Chemokines, CC