Abstract
The Churg-Strauss Syndrome is an ANCA-associated vasculitis, an inflammatory multisystem disease with preference to the respiratory tract. Peripheral and tissue eosinophilia are the pathological hallmarks of this condition. The etiopathogenesis is unknown but some cytokines appear to play a central role and could be targets for new therapies.
Copyright © 2012 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Antibodies, Antineutrophil Cytoplasmic / immunology
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Asthma / complications
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Cell Communication
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Chemokines, CC / immunology
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Chemokines, CC / metabolism
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Churg-Strauss Syndrome / complications
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Churg-Strauss Syndrome / etiology*
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Eosinophils / immunology
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Eosinophils / metabolism
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Humans
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Th17 Cells / immunology
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Th17 Cells / metabolism
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Th2 Cells / immunology
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Th2 Cells / metabolism
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Chemokines, CC