Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity

Mol Cell Endocrinol. 2013 Feb 25;366(2):204-14. doi: 10.1016/j.mce.2012.06.013. Epub 2012 Jul 11.

Abstract

The energy/fuel sensor 5'-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Aminoimidazole Carboxamide / analogs & derivatives
  • Aminoimidazole Carboxamide / pharmacology
  • Biological Transport / drug effects
  • Energy Metabolism / drug effects
  • Exercise / physiology*
  • Glucose / metabolism*
  • Glycogen / biosynthesis
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Insulin / metabolism*
  • Insulin Resistance
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism*
  • Oxidation-Reduction / drug effects
  • Ribonucleotides / pharmacology
  • Signal Transduction / drug effects

Substances

  • Hypoglycemic Agents
  • Insulin
  • Ribonucleotides
  • Aminoimidazole Carboxamide
  • Glycogen
  • AMP-Activated Protein Kinases
  • AICA ribonucleotide
  • Glucose