Eisosomes and plasma membrane organization

Mol Genet Genomics. 2012 Aug;287(8):607-20. doi: 10.1007/s00438-012-0706-8. Epub 2012 Jul 15.


Membrane compartmentalization allows the spatial segregation of different functions, such as signal transduction and protein trafficking, and ensures their fidelity and efficiency. Eisosomes constitute nanoscale furrow-like invaginations of the plasma membrane where proteins and lipids segregate. The intense interest elicited by eisosomes over the last few years has led to the identification and molecular characterization of their key constituents. This review addresses eisosome structure, functions and its implications for the mechanistic understanding of curvature-induced membrane nanodomains formation and signaling compartmentalization in living cells.

Publication types

  • Review

MeSH terms

  • Cell Membrane / chemistry*
  • Cell Membrane / metabolism*
  • Endocytosis / physiology
  • Fungi / physiology*
  • Membrane Microdomains / metabolism
  • Organelles / chemistry*
  • Organelles / metabolism*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction


  • Saccharomyces cerevisiae Proteins