Surface-modified protein nanospheres as potential antiviral agents

Dana Baram-Pinto; Sourabh Shukla; Michal Richman; Aharon Gedanken; Shai Rahimipour; Ronit Sarid

doi:10.1039/c2cc33448h

Surface-modified protein nanospheres as potential antiviral agents

Chem Commun (Camb). 2012 Aug 28;48(67):8359-61. doi: 10.1039/c2cc33448h. Epub 2012 Jul 13.

Authors

Dana Baram-Pinto¹, Sourabh Shukla, Michal Richman, Aharon Gedanken, Shai Rahimipour, Ronit Sarid

Affiliation

¹ Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel.

PMID: 22798998
DOI: 10.1039/c2cc33448h

Abstract

A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

MeSH terms

Animals
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology
Cattle
Cells, Cultured
Dose-Response Relationship, Drug
Herpesvirus 1, Human / drug effects
Mercaptoethanol / chemistry
Nanospheres / chemistry*
Serum Albumin, Bovine / chemistry*
Sulfonic Acids / chemistry
Surface Properties

Substances

Antiviral Agents
Sulfonic Acids
Serum Albumin, Bovine
Mercaptoethanol