Surface-modified protein nanospheres as potential antiviral agents

Chem Commun (Camb). 2012 Aug 28;48(67):8359-61. doi: 10.1039/c2cc33448h. Epub 2012 Jul 13.

Abstract

A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

MeSH terms

  • Animals
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology
  • Cattle
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Herpesvirus 1, Human / drug effects
  • Mercaptoethanol / chemistry
  • Nanospheres / chemistry*
  • Serum Albumin, Bovine / chemistry*
  • Sulfonic Acids / chemistry
  • Surface Properties

Substances

  • Antiviral Agents
  • Sulfonic Acids
  • Serum Albumin, Bovine
  • Mercaptoethanol