Metformin Associated B12 Deficiency

J Assoc Physicians India. 2012 Mar;60:58-60.

Abstract

According to the ADA guidelines, metformin and lifestyle modifications are the first line therapies in the treatment of type 2 diabetes mellitus. Metformin does, however, cause vitamin B-12 malabsorption, which may increase the risk of developing vitamin B-12 deficiency--a clinically important and treatable condition. Here we report a case of 60 year old diabetic male presenting with clinical features of Vitamin B-12 deficiency on long term metformin therapy, which was confirmed on investigations. Patient showed symptomatic improvement with change in treatment.

Publication types

  • Case Reports

MeSH terms

  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Humans
  • Hydroxocobalamin / therapeutic use
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / therapeutic use
  • Malabsorption Syndromes / chemically induced
  • Male
  • Metformin / adverse effects*
  • Metformin / therapeutic use
  • Middle Aged
  • Treatment Outcome
  • Vitamin B 12 / metabolism
  • Vitamin B 12 Deficiency / chemically induced*
  • Vitamin B 12 Deficiency / diagnosis
  • Vitamin B 12 Deficiency / drug therapy
  • Vitamin B Complex / therapeutic use

Substances

  • Hypoglycemic Agents
  • Vitamin B Complex
  • Metformin
  • Vitamin B 12
  • Hydroxocobalamin