Abstract
Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee. This method provides a direct access to synthesize a range of chiral cyclic amines existing in numerous important natural products and clinical drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzodiazepines / chemical synthesis
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Benzodiazepines / chemistry*
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Benzodiazepinones / chemical synthesis
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Benzodiazepinones / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Hydrogenation
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Imines / chemistry*
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Iridium / chemistry*
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Molecular Structure
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Stereoisomerism
Substances
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Benzodiazepinones
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Imines
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Benzodiazepines
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Iridium