Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application

Peptides. 2012 Oct;37(2):207-15. doi: 10.1016/j.peptides.2012.07.001. Epub 2012 Jul 16.


Antimicrobial peptides (AMPs), which are produced by several species including insects, other animals, micro-organisms and synthesis, are a critical component of the natural defense system. With the growing problem of pathogenic organisms resistant to conventional antibiotics, especially with the emergence of NDM-1, there is increased interest in the pharmacological application of AMPs. They can protect against a broad array of infectious agents, such as bacteria, fungi, parasite, virus and cancer cells. AMPs have a very good future in the application in pharmaceuticals industry and food additive. This review focuses on the AMPs from different origins in these recent years, and discusses their various functions and relative mechanisms of action. It will provide some detailed files for clinical research of pharmaceuticals industry and food additive in application.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / chemical synthesis
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Anti-Infective Agents / therapeutic use
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Bacteria / drug effects
  • Drug Industry
  • Food Additives
  • Fungi / drug effects
  • Humans
  • Neoplasms / drug therapy*
  • Parasites / drug effects
  • Viruses / drug effects


  • Anti-Infective Agents
  • Antineoplastic Agents
  • Food Additives