Neural substrates of childhood anxiety disorders: a review of neuroimaging findings

Child Adolesc Psychiatr Clin N Am. 2012 Jul;21(3):501-25. doi: 10.1016/j.chc.2012.05.002. Epub 2012 Jun 4.


The development of fear is a normative process, and significant progress has been made in identifying fear neurocircuitry. The normal development of fear goes awry in children who develop anxiety disorders, and dysfunction in fear circuitry is likely. In this article, the authors present current knowledge about the neural basis of normal fear development and reviews findings from structural and functional neuroimaging studies of childhood anxiety disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amygdala / pathology
  • Amygdala / physiopathology*
  • Anxiety Disorders / physiopathology
  • Anxiety Disorders / psychology*
  • Brain Diseases / pathology
  • Brain Diseases / physiopathology
  • Brain Diseases / psychology*
  • Child
  • Fear / physiology*
  • Functional Neuroimaging / methods*
  • Humans
  • Prefrontal Cortex / pathology
  • Prefrontal Cortex / physiopathology*