LKB1-AMPK axis revisited

Cell Res. 2012 Dec;22(12):1617-20. doi: 10.1038/cr.2012.108. Epub 2012 Jul 17.

Abstract

The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis, AMPK. While mutational inactivation of LKB1 promotes the development of many types of epithelial cancer, a recent report in Nature by Jeon et al. demonstrates that the LKB1-AMPK pathway can also have an unexpected positive role in tumorigenesis, acting to maintain metabolic homeostasis and attenuate oxidative stress thereby supporting the survival of cancer cells.

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Acetyl-CoA Carboxylase / metabolism
  • Acetyltransferases / metabolism
  • Cell Line, Tumor
  • Energy Metabolism
  • Humans
  • Mutation
  • NADP / metabolism
  • Oxidative Stress
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • NADP
  • Acetyltransferases
  • aminoglycoside N1-acetyltransferase
  • STK11 protein, human
  • TOR Serine-Threonine Kinases
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • ACACB protein, human
  • Acetyl-CoA Carboxylase