Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Oct;46(2):374-92.
doi: 10.1007/s12035-012-8299-0. Epub 2012 Jul 17.

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

Affiliations
Review

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

Antonio Luchicchi et al. Mol Neurobiol. .

Abstract

Since the discovery of endocannabinoids and their receptors, two major members of the endocannabinoid family, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been regarded almost as twin brothers. Pharmacological properties were initially considered to be similar, as these molecules were believed mutually exchangeable and almost indistinguishable in the regulation of synaptic functions, such as long- and short-term synaptic plasticity, and in behavioral aspects, such as learning and memory, reward and addiction, antinociception, and anxiety. In recent years, however, endocannabinoid signaling specificity began to emerge, in particular, due to the production of genetically engineered mice lacking key enzymes in endocannabinoid synthesis or degradation, together with the development of selective inhibitors of AEA or 2-AG catabolic enzymes. Evidence now suggests that AEA and 2-AG possess specific pharmacological properties, are engaged in different forms of synaptic plasticity, and take part in different behavioral functions. In this review, we provide an overview on similarities and specificities of the two endocannabinoids in the CNS and on the unresolved questions concerning their role in synaptic signaling.

Similar articles

See all similar articles

Cited by 37 articles

See all "Cited by" articles

References

    1. Pharmacol Biochem Behav. 2011 Mar;98 (1):21-7 - PubMed
    1. Neuropharmacology. 2011 Oct-Nov;61(5-6):1016-25 - PubMed
    1. Br J Pharmacol. 2012 Apr;165(8):2549-60 - PubMed
    1. J Neurosci. 1992 Oct;12(10):4122-32 - PubMed
    1. J Neurochem. 2007 Dec;103(5):1907-16 - PubMed

Publication types

LinkOut - more resources

Feedback