Tyrosyl phosphorylation toggles a Runx1 switch

Genes Dev. 2012 Jul 15;26(14):1520-6. doi: 10.1101/gad.198051.112.

Abstract

The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 1587-1601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / metabolism*
  • Cell Differentiation / physiology*
  • Core Binding Factor Alpha 2 Subunit / metabolism*
  • Humans
  • Megakaryocytes / metabolism*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / metabolism*
  • Signal Transduction / physiology*
  • src-Family Kinases / metabolism*

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Runx1 protein, mouse
  • src-Family Kinases
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Ptpn11 protein, mouse