Abstract
The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 1587-1601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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CD8-Positive T-Lymphocytes / metabolism*
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Cell Differentiation / physiology*
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Core Binding Factor Alpha 2 Subunit / metabolism*
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Humans
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Megakaryocytes / metabolism*
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Protein Tyrosine Phosphatase, Non-Receptor Type 11 / metabolism*
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Signal Transduction / physiology*
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src-Family Kinases / metabolism*
Substances
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Core Binding Factor Alpha 2 Subunit
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Runx1 protein, mouse
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src-Family Kinases
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Ptpn11 protein, mouse