Pain is a common occurrence after tooth extraction and is usually localized to the extraction site. However, clinical experience shows that patients may also have pain in the head or neck in the weeks after this procedure. The authors present a case representative of these findings. In the case, cranial and cervical somatic dysfunction in a patient who had undergone tooth extraction was resolved through the use of osteopathic manipulative treatment. This case emphasizes the need to include a dental history when evaluating head and neck pain as part of comprehensive osteopathic medical care. The case can also serve as a foundation for a detailed discussion regarding how to effectively incorporate osteopathic manipulative treatment into primary care practice for patients who present with head or neck pain after tooth extraction.