Abstract
In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Amino-5-phosphonovalerate / pharmacology
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Analysis of Variance
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Animals
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Association Learning / drug effects
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Association Learning / physiology
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Conditioning, Operant / drug effects
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Conditioning, Operant / physiology*
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Cues
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Early Growth Response Protein 1 / metabolism
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Excitatory Amino Acid Antagonists / pharmacology
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Gyrus Cinguli / drug effects
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Gyrus Cinguli / physiology*
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Hippocampus / drug effects
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Hippocampus / physiology*
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Male
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Mental Recall / drug effects
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Mental Recall / physiology*
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Neural Pathways / drug effects
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Neural Pathways / physiology
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Rats
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Reaction Time / drug effects
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Reward
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Time Factors
Substances
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Early Growth Response Protein 1
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Egr1 protein, rat
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Excitatory Amino Acid Antagonists
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6-Cyano-7-nitroquinoxaline-2,3-dione
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2-Amino-5-phosphonovalerate