HIV treatment as prevention: debate and commentary--will early infection compromise treatment-as-prevention strategies?

PLoS Med. 2012;9(7):e1001232. doi: 10.1371/journal.pmed.1001232. Epub 2012 Jul 10.


Universal HIV testing and immediate antiretroviral therapy for infected individuals has been proposed as a way of reducing the transmission of HIV and thereby bringing the HIV epidemic under control. It is unclear whether transmission during early HIV infection--before individuals are likely to have been diagnosed with HIV and started on antiretroviral therapy--will compromise the effectiveness of treatment as prevention. This article presents two opposing viewpoints by Powers, Miller, and Cohen, and Williams and Dye, followed by a commentary by Fraser.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Anti-HIV Agents / pharmacology*
  • Anti-HIV Agents / therapeutic use
  • HIV Infections / drug therapy*
  • HIV Infections / prevention & control*
  • Humans
  • Time Factors
  • Treatment Outcome


  • Anti-HIV Agents