Regulation of hemodynamic parameters under conditions of systemic administration of angiotensin II and angiotensin IV to rats after carotid glomectomy

Bull Exp Biol Med. 2011 Nov;152(1):9-11. doi: 10.1007/s10517-011-1439-0.
[Article in English, Russian]


Systemic administration of angiotensin II was followed by an increase in systolic BP and HR in rats with carotid glomectomy, the time of attaining maximum values in treated animals was much higher than in sham-operated controls. Injection of angiotensin IV slightly reduced systolic BP in sham-operated animals and increased it in rats with carotid glomectomy. The involvement of the local renin-angiotensin system of the carotid body in systemic mechanisms of hemodynamics regulation is discussed.

MeSH terms

  • Angiotensin II / analogs & derivatives*
  • Angiotensin II / pharmacology*
  • Angiotensin II / physiology
  • Animals
  • Blood Pressure / drug effects
  • Carotid Body / drug effects
  • Carotid Body / physiology*
  • Heart Rate / drug effects
  • Hemodynamics
  • Male
  • Rats
  • Rats, Wistar
  • Vasomotor System / drug effects
  • Vasomotor System / physiology


  • Angiotensin II
  • angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-