Effects and mechanisms of hemopoiesis-stimulating activity of immobilized oligonucleotides under conditions of cytostatic myelosuppression
Bull Exp Biol Med. 2012 Feb;152(4):451-5.
doi: 10.1007/s10517-012-1551-9.
[Article in
English,
Russian]
Authors
A M Dygai
1
, V E Goldberg, A V Artamonov, A A Bekarev, E I Vereschagin, P G Madonov, E G Skurikhin, O V Pershina, T V Andreeva, E S Khmelevskaya, N N Ermakova
Affiliation
- 1 Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. dygay@rambler.ru
Abstract
Hemopoiesis-stimulating activity of immobilized oligonucleotide preparation was studied on the model of cytostatic myelosuppression induced by injection of cyclophosphamide and 5-fluorouracil. Immobilized oligonucleotides stimulated regeneration of erythro- and granulocytopoiesis in the bone marrow under conditions of cytostatic treatment. The counts of neutrophilic granulocytes and platelets in the peripheral blood increased. The stimulatory effect of the drug was more manifest in animals with active behavior. The mechanism of immobilized oligonucleotide effect was based on stimulation of functional activity of erythroid and granulocytic macrophage precursors.
MeSH terms
-
Administration, Oral
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Animals
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Blood Platelets / cytology
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Blood Platelets / drug effects
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Bone Marrow / drug effects
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Bone Marrow / physiology
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Cell Count
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Cyclophosphamide / administration & dosage
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Cytostatic Agents / administration & dosage
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Erythropoiesis / drug effects*
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Erythropoiesis / physiology
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Fluorouracil / administration & dosage
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Granulocytes / cytology
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Granulocytes / drug effects
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Hematinics / administration & dosage*
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Hematinics / chemistry
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Injections, Intraperitoneal
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Leukocytes, Mononuclear / cytology
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Leukocytes, Mononuclear / drug effects
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Mice
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Mice, Inbred CBA
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Myelopoiesis / drug effects*
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Myelopoiesis / physiology
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Oligonucleotides / administration & dosage*
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Oligonucleotides / chemistry
Substances
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Cytostatic Agents
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Hematinics
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Oligonucleotides
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Cyclophosphamide
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Fluorouracil