Role of peptides in epigenetic regulation of gene activities in ontogeny

V Kh Khavinson; V V Malinin; B F Vanyushin

doi:10.1007/s10517-012-1555-5

Role of peptides in epigenetic regulation of gene activities in ontogeny

Bull Exp Biol Med. 2012 Feb;152(4):470-4. doi: 10.1007/s10517-012-1555-5.

[Article in English, Russian]

Authors

V Kh Khavinson¹, V V Malinin, B F Vanyushin

Affiliation

¹ I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

PMID: 22803113
DOI: 10.1007/s10517-012-1555-5

Abstract

The authors develop a new concept most fully reflecting the evolutional and biological role of peptides in the organism. Wide spectrum of peptide effects realized through regulation of the expression of certain genes is aimed at the maintenance of homeostasis, inhibition of the genetic aging program realization, and lifespan prolongation.

MeSH terms

Aging / genetics*
Binding Sites
Biological Evolution
DNA / genetics*
DNA / metabolism
Epigenesis, Genetic*
Epigenomics
Homeostasis / genetics
Humans
Oligopeptides / genetics*
Oligopeptides / metabolism
Protein Binding

Substances

Oligopeptides
DNA