Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats

Bull Exp Biol Med. 2012 Mar;152(5):560-3. doi: 10.1007/s10517-012-1574-2.
[Article in English, Russian]

Abstract

Maternal deprivation in the early postnatal period significantly affects the behavior and development of different animals. Here we studied delayed effects of daily maternal deprivation (5 h/day) on physical development and behavior of white rats during postnatal days 1 to 14. Here we studied the possibility of reducing the negative consequences of deprivation by daily intranasal treatment with Semax, an analog of ACTH(4-10), in a dose of 0.05 mg/kg from postnatal days 15 to 28. It was found that maternal deprivation decelerated the growth of young rats, boosted physical activity and emotional reactivity in novel environment, and increased anxiety in one-month-old animals. Semax weakened the impact of deprivation on animal body weight and normalized the levels of anxiety in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Adrenocorticotropic Hormone / administration & dosage
  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Animals
  • Animals, Newborn
  • Anxiety / prevention & control*
  • Anxiety / psychology
  • Behavior, Animal / drug effects
  • Body Weight / drug effects
  • Emotions / drug effects
  • Female
  • Male
  • Maternal Deprivation*
  • Maze Learning / drug effects
  • Motor Activity / drug effects
  • Nootropic Agents / administration & dosage*
  • Peptide Fragments / administration & dosage*
  • Rats

Substances

  • Nootropic Agents
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone