Effects of reversible inhibition of cholinesterase and nicotine on mouse mortality and blood levels of proinflammatory cytokines during the early phase of sepsis
Bull Exp Biol Med. 2012 Mar;152(5):600-2.
doi: 10.1007/s10517-012-1585-z.
[Article in
English,
Russian]
Affiliation
- 1 V. I. Razumovskii State Medical University, Saratov, Russia. pfzabrodsky@gmail.com
Abstract
Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL(50)injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-α, IL-1β, and IL-6.
MeSH terms
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Animals
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Animals, Outbred Strains
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Cholinesterase Inhibitors / administration & dosage*
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Drug Therapy, Combination
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Escherichia coli Infections / drug therapy*
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Escherichia coli Infections / immunology
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Escherichia coli Infections / microbiology
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Escherichia coli Infections / mortality
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Female
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Interleukin-1beta / blood
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Interleukin-1beta / immunology
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Interleukin-6 / blood
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Interleukin-6 / immunology
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Male
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Mice
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Neostigmine / administration & dosage*
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Nicotine / administration & dosage*
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Nicotinic Agonists / administration & dosage*
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Sepsis / drug therapy*
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Sepsis / immunology
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Sepsis / microbiology
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Sepsis / mortality
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Survival Rate
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Time Factors
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Tumor Necrosis Factor-alpha / blood
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Tumor Necrosis Factor-alpha / immunology
Substances
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Cholinesterase Inhibitors
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Interleukin-1beta
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Interleukin-6
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Nicotinic Agonists
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Tumor Necrosis Factor-alpha
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Neostigmine
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Nicotine