Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression
Bull Exp Biol Med. 2012 Mar;152(5):633-6.
doi: 10.1007/s10517-012-1595-x.
[Article in
English,
Russian]
Affiliation
- 1 Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Abstract
Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results demonstrate association between CYP2D6 (1846G/A) genotype and rapid cirrhosis development and indicate the necessity of studying the mechanisms underlying this association.
MeSH terms
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Adult
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Aged
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Cytochrome P-450 CYP2D6 / genetics*
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Disease Progression
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Female
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Genetic Markers
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Genetic Predisposition to Disease
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Hepacivirus / physiology
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Hepatitis B / complications
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Hepatitis B / genetics*
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Hepatitis B / pathology
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Hepatitis B / virology
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Hepatitis B virus / physiology
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Hepatitis C / complications
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Hepatitis C / genetics*
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Hepatitis C / pathology
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Hepatitis C / virology
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Hepatitis, Alcoholic / complications
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Hepatitis, Alcoholic / genetics*
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Hepatitis, Alcoholic / pathology
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Heterozygote
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Homozygote
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Humans
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Liver / enzymology
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Liver / pathology*
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Liver / virology
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Liver Cirrhosis / etiology
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Liver Cirrhosis / genetics*
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Liver Cirrhosis / pathology
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Liver Cirrhosis / virology
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Male
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Middle Aged
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Polymorphism, Single Nucleotide
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Siberia
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White People
Substances
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Genetic Markers
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Cytochrome P-450 CYP2D6