Mechanisms of antioxidant effect of natural sesquiterpene lactone and alkaloid derivatives

Bull Exp Biol Med. 2012 Apr;152(6):720-2. doi: 10.1007/s10517-012-1615-x.
[Article in English, Russian]

Abstract

We performed screening of potential antioxidants among natural lactone and alkaloid derivatives and characterized their antioxidant effects. The substances exhibiting antioxidant and metal-chelating potential, in particular, tryptamine derivatives, are promising neuroprotector agents.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / pharmacology*
  • Animals
  • Animals, Outbred Strains
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Brain / drug effects
  • Brain / metabolism
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacology*
  • Free Radicals / antagonists & inhibitors
  • Free Radicals / metabolism
  • Lipid Peroxidation / drug effects
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology*
  • Rats
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology*
  • Structure-Activity Relationship
  • Thiobarbiturates
  • Tissue Extracts / agonists
  • Tissue Extracts / antagonists & inhibitors
  • Tissue Extracts / metabolism*

Substances

  • Alkaloids
  • Antioxidants
  • Chelating Agents
  • Free Radicals
  • Neuroprotective Agents
  • Sesquiterpenes
  • Thiobarbiturates
  • Tissue Extracts
  • thiobarbituric acid