Mechanisms of antioxidant effect of natural sesquiterpene lactone and alkaloid derivatives
Bull Exp Biol Med. 2012 Apr;152(6):720-2.
doi: 10.1007/s10517-012-1615-x.
[Article in
English,
Russian]
Affiliation
- 1 Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. neganova83@mail.ru
Abstract
We performed screening of potential antioxidants among natural lactone and alkaloid derivatives and characterized their antioxidant effects. The substances exhibiting antioxidant and metal-chelating potential, in particular, tryptamine derivatives, are promising neuroprotector agents.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology*
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Animals
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Animals, Outbred Strains
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Brain / drug effects
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Brain / metabolism
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Chelating Agents / chemistry
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Chelating Agents / pharmacology*
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Free Radicals / antagonists & inhibitors
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Free Radicals / metabolism
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Lipid Peroxidation / drug effects
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology*
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Rats
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology*
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Structure-Activity Relationship
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Thiobarbiturates
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Tissue Extracts / agonists
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Tissue Extracts / antagonists & inhibitors
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Tissue Extracts / metabolism*
Substances
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Alkaloids
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Antioxidants
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Chelating Agents
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Free Radicals
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Neuroprotective Agents
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Sesquiterpenes
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Thiobarbiturates
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Tissue Extracts
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thiobarbituric acid