Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy

Ir Med J. 2012 May;105(5):148-9.


We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the first time this treatment strategy has been employed successfully in an Irish centre.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / therapy*
  • Anti-Bacterial Agents / therapeutic use
  • Antineoplastic Agents / therapeutic use*
  • Biopsy
  • Boronic Acids / therapeutic use*
  • Bortezomib
  • Combined Modality Therapy
  • Female
  • Humans
  • Ireland
  • Kidney Function Tests
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / drug therapy
  • Pyrazines / therapeutic use*
  • Renal Dialysis / methods*


  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Boronic Acids
  • Pyrazines
  • Bortezomib