Macrophage activation syndrome triggered by primary disseminated toxoplasmosis

Scand J Infect Dis. 2012 Dec;44(12):1001-4. doi: 10.3109/00365548.2012.691208. Epub 2012 Jul 17.

Abstract

We report the case of a patient with disseminated toxoplasmosis who presented with cervical lymphadenopathies and pneumonia. Although the infection was successfully treated with co-trimoxazole, the patient developed reactive macrophage activation syndrome (rMAS). To our knowledge, this is the first reported case of rMAS triggered by toxoplasmosis in the medical literature.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents / administration & dosage
  • Female
  • Humans
  • Lymphatic Diseases / diagnosis
  • Lymphatic Diseases / pathology
  • Macrophage Activation Syndrome / diagnosis*
  • Macrophage Activation Syndrome / parasitology
  • Macrophage Activation Syndrome / pathology*
  • Middle Aged
  • Neck / pathology
  • Pneumonia / diagnosis
  • Pneumonia / pathology
  • Toxoplasmosis / complications*
  • Toxoplasmosis / drug therapy
  • Toxoplasmosis / pathology*
  • Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage

Substances

  • Anti-Infective Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination