Structured management strategy based on the Gastro-oesophageal Reflux Disease (GERD) Questionnaire (GerdQ) vs. usual primary care for GERD: pooled analysis of five cluster-randomised European studies

Int J Clin Pract. 2012 Sep;66(9):897-905. doi: 10.1111/j.1742-1241.2012.02992.x. Epub 2012 Jul 16.


Background: Response to treatment among primary care patients with gastro-oesophageal disease (GERD) is variable.

Aim: The GERD Management Project (GMP) evaluated the effectiveness of a structured management approach to GERD vs. standard treatment (usual care).

Methods: Data from five cluster-randomised clinical trials in adult primary care patients with symptoms of GERD were pooled. The structured pathway was based on the self-administered GERD Questionnaire (GerdQ) and was compared with standard treatment.

Results: 1734 patients were enrolled (structured treatment, n=834; standard treatment, n=900). The difference in the mean GerdQ score change from baseline favoured the structured pathway (-0.61; 95% CI: -0.88, -0.34; p<0.001). The odds ratio for an indication for treatment revision at the end of follow-up (structured vs. standard treatment) was 0.39 (95% CI: 0.29, 0.52; p=0.001).

Conclusions: Management of primary care patients with GERD can be improved by systematic stratification of patients using a patient management tool such as the GerdQ.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis
  • Critical Pathways
  • Female
  • Gastroesophageal Reflux / therapy*
  • Humans
  • Male
  • Middle Aged
  • Primary Health Care
  • Randomized Controlled Trials as Topic
  • Surveys and Questionnaires