Intravenous immunoglobulin for repeated IVF failure and unexplained infertility

Am J Reprod Immunol. 2012 Sep;68(3):218-25. doi: 10.1111/j.1600-0897.2012.01169.x. Epub 2012 Jul 17.


Problem: We set out to determine whether intravenous immunoglobulin (IVIG) improves in vitro fertilization (IVF) success rates in women with a difficult history of multiple (≥ 2) prior IVF failures and /or 'unexplained' infertility.

Method of study: A total of 229 women with multiple IVF failures (3.3 ± 2.1) and/or unexplained infertility (3.8 ± 2.7 years) were given IVIG on the day of egg retrieval, and the subsequent IVF success rates were compared with published success rates from the Canadian database (CARTR).

Results: The pregnancy rate per IVIG-treated cycle was 60.3% (138/229), and the live birth rate per IVIG-treated cycle was 40.2% (92/229). This is a significantly higher success rate compared to the Canadian average (30% live birth rate; CARTR statistics from 2010; P = 0.0012). In cases where a single embryo was transferred, pregnancy rate using IVIG was almost twofold the CARTR pregnancy rate [(61%(20/33) to 34.9% (428/1225)]. In cases where two high quality (≥ Grade 3) day 5 blastocysts were transferred, nearly a 100% pregnancy rate was achieved using IVIG (30/31).

Conclusion: IVIG may be a useful treatment option for patients with previous IVF failure and/ or unexplained infertility. The data confirm previously published studies at other centers.

MeSH terms

  • Adult
  • Blastocyst / drug effects
  • Blastocyst / immunology
  • Databases, Factual
  • Embryo Transfer
  • Female
  • Fertilization in Vitro*
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunologic Factors / administration & dosage*
  • Infertility / drug therapy*
  • Infertility / immunology
  • Ovum / drug effects
  • Ovum / immunology
  • Pregnancy
  • Pregnancy Rate
  • Treatment Failure


  • Immunoglobulins, Intravenous
  • Immunologic Factors