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, 14 (4), 107

Is the Tide Turning Against Breast Screening?


Is the Tide Turning Against Breast Screening?

Karsten Jørgensen. Breast Cancer Res.


Herein I argue that mammographic screening has not delivered on its fundamental premise: to reduce the incidence of advanced breast cancer. Indeed, achieving this goal is required if screening is to reduce breast cancer mortality or mastectomy use. Rather, screening has caused substantial increases in the incidence of in situ and early invasive cancers. Moreover, evidence indicates that these screen-detected cancers are unlikely to be cases that were 'caught early', but instead represent women who would not have been diagnosed in the absence of screening and who, as a result, have received harmful, unnecessary treatment. If true, these observations raise the specter that screening creates breast cancer patients and that this practice carries little or no benefit.

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Cited by 4 PubMed Central articles


    1. Nederend J, Duijm LEM, Voogd AC, Groenewoud JH, Jansen FH, Louwman MWJ. Trends in incidence and detection of advanced breast cancer at biennial screening mammography in The Netherlands: a population based study. Breast Cancer Res. 2012;14:R10. doi: 10.1186/bcr3091. - DOI - PMC - PubMed
    1. Autier P, Boniol M, Middleton R, Doré JF, Héry C, Zheng T, Gavin A. Advanced breast cancer incidence following population based mammographic screening. Ann Oncol. 2011;14:1726–1735. doi: 10.1093/annonc/mdq633. - DOI - PMC - PubMed
    1. Gøtzsche PC, Jørgensen KJ, Zahl PH, Mæhlen J. Why mammography screening has not lived up to expectations from the randomised trials. Cancer Causes Control. 2012;14:15–21. doi: 10.1007/s10552-011-9867-8. - DOI - PubMed
    1. Autier P, Boniol M, Gavin A, Vatten LJ. Breast cancer mortality in neighbouring European countries with different levels of screening but similar access to treatment: trend analysis of WHO mortality database. BMJ. 2011;14:d4411. doi: 10.1136/bmj.d4411. - DOI - PMC - PubMed
    1. Jørgensen KJ, Zahl PH, Gøtzsche PC. Breast cancer mortality in organized mammography screening in Denmark. A comparative study. BMJ. 2010;14:c1241. doi: 10.1136/bmj.c1241. - DOI - PMC - PubMed

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