Ribonucleoside 3'-phosphates as pro-moieties for an orally administered drug

ChemMedChem. 2012 Aug;7(8):1361-4. doi: 10.1002/cmdc.201200243. Epub 2012 Jul 13.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Oral
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacteroides Infections / drug therapy
  • Bacteroides fragilis / drug effects
  • Humans
  • Kinetics
  • Metronidazole / chemistry
  • Metronidazole / pharmacology
  • Metronidazole / therapeutic use
  • Microbial Sensitivity Tests
  • Prodrugs / chemistry
  • Prodrugs / pharmacology
  • Prodrugs / therapeutic use
  • Ribonuclease, Pancreatic / metabolism
  • Ribonucleotides / chemistry
  • Ribonucleotides / pharmacology*
  • Ribonucleotides / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Prodrugs
  • Ribonucleotides
  • Metronidazole
  • Ribonuclease, Pancreatic