Insulin-like growth factors 1 and 2 regulate expression of β-casein in vitro in mouse mammary epithelial cells

Bull Exp Biol Med. 2011 Dec;152(2):202-5. doi: 10.1007/s10517-011-1488-4.
[Article in English, Russian]


We studied the role of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) in functional differentiation of HC11 mouse mammary gland cells. It was found that both IGF-1 and IGF-2 activate the expression of milk protein β-casein in the presence of prolactin and hydrocortisone. It was found that β-casein expression is accompanied by cyclin D1 coexpression.

MeSH terms

  • Animals
  • Blotting, Western
  • Caseins / metabolism*
  • Cell Line
  • Cyclin D1 / metabolism
  • Epithelial Cells / drug effects
  • Epithelial Cells / metabolism*
  • Hydrocortisone / pharmacology
  • Insulin-Like Growth Factor I / metabolism*
  • Insulin-Like Growth Factor II / metabolism*
  • Mammary Glands, Animal
  • Mice
  • Prolactin / pharmacology


  • Caseins
  • Cyclin D1
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II
  • Prolactin
  • Hydrocortisone