Inflammation, endothelial function and atherosclerosis in rheumatoid arthritis

Arthritis Res Ther. 2012 Jul 19;14(4):122. doi: 10.1186/ar3891.


Different techniques have proven to be useful in determining the presence of subclinical cardiovascular disease in patients with rheumatoid arthritis (RA). Doppler imaging with iontophoresis of acetylcholine and flow-mediated, endothelium-dependent vasodilation give information on endothelial dysfunction, an early step in the atherogenesis process. However, there is no good correlation between these two surrogate markers of cardiovascular disease in RA. A single determination of routine laboratory markers of inflammation does not seem to relate to endothelial function in RA. Further research is needed to determine whether microvascular endothelial function is a better predictor of cardiovascular outcome than macrovascular endothelial function in patients with RA.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy*
  • Cardiovascular Diseases / epidemiology*
  • Endothelium, Vascular / drug effects*
  • Female
  • Humans
  • Inflammation / pathology*
  • Male


  • Antirheumatic Agents