A New Era of GPCR Structural and Chemical Biology

Nat Chem Biol. 2012 Jul 18;8(8):670-3. doi: 10.1038/nchembio.1025.

Abstract

G protein-coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity of ligand recognition and receptor activation of G proteins.

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Cell Membrane / physiology*
  • Crystallography
  • Drug Discovery
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism
  • Gene Expression Regulation
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Protein Folding
  • Protein Stability
  • Receptors, G-Protein-Coupled / chemistry*
  • Receptors, G-Protein-Coupled / classification
  • Receptors, G-Protein-Coupled / physiology*
  • Signal Transduction

Substances

  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins