Draft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein

J Bacteriol. 2012 Aug;194(15):4144. doi: 10.1128/JB.00797-12.

Abstract

Streptomyces globisporus C-1027 is the producer of antitumor antibiotic C-1027, a nine-membered enediyne-containing compound. Here we present a draft genome sequence of S. globisporus C-1027 containing the intact biosynthetic gene cluster for this antibiotic. The genome also carries numerous sets of genes for the biosynthesis of diverse secondary metabolites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / metabolism
  • Bacterial Proteins / metabolism*
  • Biosynthetic Pathways / genetics
  • DNA, Bacterial / chemistry*
  • DNA, Bacterial / genetics*
  • Enediynes / metabolism*
  • Genome, Bacterial*
  • Molecular Sequence Data
  • Multigene Family
  • Sequence Analysis, DNA*
  • Streptomyces / genetics
  • Streptomyces / isolation & purification
  • Streptomyces / metabolism*

Substances

  • Antineoplastic Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Enediynes
  • antitumor protein, Streptomyces

Associated data

  • GENBANK/AJUO01000000