New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine

V A Shibnev; T M Garaev; M P Finogenova; E S Shevchenko; E I Burtseva

doi:10.1007/s10517-012-1684-x

New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine

Bull Exp Biol Med. 2012 Jun;153(2):233-5. doi: 10.1007/s10517-012-1684-x.

[Article in English, Russian]

Authors

V A Shibnev¹, T M Garaev, M P Finogenova, E S Shevchenko, E I Burtseva

Affiliation

¹ D. I. Ivanovsky Institute of Virology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.

PMID: 22816091
DOI: 10.1007/s10517-012-1684-x

Abstract

New adamantane derivatives with amino acid residues and other bifunctional compounds were synthesized and their antiviral activity towards influenza A(H1N1)pdm and A(H3N2) viruses was studied. Some of these adamantane derivatives completely suppressed replication of remantadine-resistant influenza A virus strains.

MeSH terms

Adamantane / analogs & derivatives*
Adamantane / pharmacology
Antiviral Agents / pharmacology*
Drug Resistance, Viral
Influenza A Virus, H1N1 Subtype / drug effects*
Influenza A Virus, H3N2 Subtype / drug effects*
Rimantadine / pharmacology

Substances

Antiviral Agents
Rimantadine
Adamantane