Superoxide scavenging activity of plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1)

Biochemistry (Mosc). 2012 Jul;77(7):776-8. doi: 10.1134/S0006297912070103.

Abstract

The plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) has the ability to scavenge superoxide anion radical. This ability is manifested both in vitro and in vivo in experiments with the bacterium Escherichia coli. The protective effect of SkQ1 in vivo significantly exceeds that of ascorbic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascorbic Acid / pharmacology
  • Dose-Response Relationship, Drug
  • Escherichia coli / cytology
  • Escherichia coli / drug effects*
  • Escherichia coli / metabolism
  • Free Radical Scavengers / metabolism
  • Free Radical Scavengers / pharmacology*
  • Plastoquinone / analogs & derivatives*
  • Plastoquinone / metabolism
  • Plastoquinone / pharmacology
  • Superoxides / metabolism
  • Superoxides / pharmacology*

Substances

  • 10-(6'-plastoquinonyl)decyltriphenylphosphonium
  • Free Radical Scavengers
  • Superoxides
  • Plastoquinone
  • Ascorbic Acid