Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

Phytochemistry. 2012 Oct;82:118-27. doi: 10.1016/j.phytochem.2012.06.014. Epub 2012 Jul 18.

Abstract

Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H(37)Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / metabolism*
  • Antitubercular Agents / pharmacology*
  • Juglandaceae / chemistry
  • Juglandaceae / metabolism*
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Plant Extracts / chemistry
  • Plant Extracts / metabolism*
  • Plant Extracts / pharmacology*
  • Plant Stems / chemistry
  • Plant Stems / metabolism*

Substances

  • Antitubercular Agents
  • Plant Extracts