Early juvenile idiopathic arthritis

Rheum Dis Clin North Am. 2012 May;38(2):355-72. doi: 10.1016/j.rdc.2012.04.006. Epub 2012 Jun 9.


Early juvenile idiopathic arthritis (JIA) is important to recognize as timely diagnosis and treatment improves prognosis. It is a misconception that complications of JIA arise only from long-standing disease and that children will outgrow it. Early aggressive treatment is the paradigm as early disease activity has long-term consequences. There are predictors of persistent disease and joint erosions that may identify patients at higher risk. Control of disease activity within the first 6 months of onset confers improved clinical course and outcomes. The treatment perspective is thus one of early aggressive treatment for induction of disease control and ultimately remission.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Juvenile / diagnosis*
  • Arthritis, Juvenile / drug therapy*
  • Arthritis, Juvenile / physiopathology
  • Disease Progression
  • Early Diagnosis
  • Humans
  • Joints / pathology
  • Joints / physiopathology
  • Prognosis
  • Secondary Prevention*
  • Severity of Illness Index


  • Antibodies, Monoclonal
  • Antirheumatic Agents