Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery

Adv Skin Wound Care. 2012 Aug;25(8):349-70. doi: 10.1097/01.ASW.0000418541.31366.a3.


This is the second of 2 articles that discuss the biology and pathophysiology of wound healing, reviewing the role that growth factors play in this process and describing the current methods for growth factor delivery into the wound bed.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Drug Delivery Systems / methods*
  • Epidermal Growth Factor / therapeutic use
  • Humans
  • Intercellular Signaling Peptides and Proteins / therapeutic use*
  • Platelet-Derived Growth Factor / therapeutic use
  • Signal Transduction
  • Treatment Failure
  • Vascular Endothelial Growth Factor A / therapeutic use
  • Wound Healing*
  • Wounds and Injuries / drug therapy*
  • Wounds and Injuries / pathology
  • Wounds and Injuries / therapy


  • Intercellular Signaling Peptides and Proteins
  • Platelet-Derived Growth Factor
  • Vascular Endothelial Growth Factor A
  • Epidermal Growth Factor