Cytotoxic sesterterpenoids from a sponge Hippospongia sp

Mar Drugs. 2012 May;10(5):987-997. doi: 10.3390/md10050987. Epub 2012 Apr 27.


One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane-type sesterterpenes (3-8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3-5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.

Keywords: Hippospongia; scalarane; sesterterpenoid; sponge.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor / methods
  • Humans
  • K562 Cells
  • Magnetic Resonance Spectroscopy / methods
  • Porifera / chemistry*
  • Sesterterpenes / chemistry*
  • Sesterterpenes / isolation & purification
  • Sesterterpenes / pharmacology*


  • Sesterterpenes