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. 2012 Jun;10(6):1203-1211.
doi: 10.3390/md10061203. Epub 2012 May 25.

Simplexins P-S, eunicellin-based diterpenes from the soft coral Klyxum simplex

Affiliations

Simplexins P-S, eunicellin-based diterpenes from the soft coral Klyxum simplex

Shwu-Li Wu et al. Mar Drugs. 2012 Jun.

Erratum in

  • Mar Drugs. 2013 Dec;11(12):5087-8

Abstract

Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.

Keywords: Klyxum simplex; cytotoxicity; eunicellin-based diterpenes; soft coral.

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Figures

Chart 1
Chart 1
Structures of Metabolites 1–5.
Figure 1
Figure 1
Key 1H–1H COSY and HMBC correlations of 1 and 2.
Figure 2
Figure 2
Selective NOESY correlations of 1 and 3.

References

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