Simplexins P-S, eunicellin-based diterpenes from the soft coral Klyxum simplex
- PMID: 22822367
- PMCID: PMC3397434
- DOI: 10.3390/md10061203
Simplexins P-S, eunicellin-based diterpenes from the soft coral Klyxum simplex
Erratum in
- Mar Drugs. 2013 Dec;11(12):5087-8
Abstract
Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
Keywords: Klyxum simplex; cytotoxicity; eunicellin-based diterpenes; soft coral.
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References
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- Wang G.-H., Sheu J.-H., Chiang M.Y., Lee T.-J. Pachyclavulariaenones A–C, three novel diterpenoids from the soft coral Pachyclavularia violacea. Tetrahedron Lett. 2001;42:2333–2336.
-
- Su J.-H., Huang H.-C., Chao C.-H., Yan L.-Y., Wu Y.-C., Wu C.-C., Sheu J.-H. Vigulariol, a new metabolite from the sea pen Vigularia juncea. Bull. Chem. Soc. Jpn. 2005;78:877–879. doi: 10.1246/bcsj.78.877. - DOI
-
- Chen B.-W., Chang S.-M., Huang C.-Y., Chao C.-H., Su J.-H., Wen Z.-H., Hsu C.-H., Dai C.-F., Wu Y.-C., Sheu J.-H. Hirsutalins A–H, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta. J. Nat. Prod. 2010;73:1785–1791. - PubMed
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