Candida albicans interface infection after deep anterior lamellar keratoplasty

Indian J Ophthalmol. 2012 Jul;60(4):328-30. doi: 10.4103/0301-4738.98723.


The clinical features of interface Candida keratitis after deep anterior lamellar keratoplasty (DALK), may imitate rejection or crystalline keratopathy. We report here an 18-year-old woman presented with red eye, 4 months after undergoing DALK. Slit lamp examination revealed keratic precipitates (KPs) and conjunctival injection. She was prescribed corticosteroid treatment for endothelial rejection by another ophthalmologist because of misdiagnosis, but suffered a recurrence of symptoms after reduction of the corticosteroid treatment. At that time, she was referred to our office. The recurrence persisted despite antibiotic and antifungal therapies. Ten days after treatment with interface irrigation with amphotericin, the infiltration and hypopyon were resolved. Topical steroid was added after 3 months of antifungal monotherapy. Irrigant cultures confirmed the presence of Candida albicans. The corneal graft appeared semi-clear with no signs of infection at 17-month follow-up. We recommend a close follow-up and a timely intervention to prevent the need for more invasive treatment such as penetrating keratoplasty.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antifungal Agents / therapeutic use*
  • Candida albicans / isolation & purification*
  • Candidiasis / diagnosis
  • Candidiasis / drug therapy
  • Candidiasis / etiology*
  • Cornea / microbiology
  • Cornea / surgery
  • Corneal Transplantation / adverse effects*
  • Diagnosis, Differential
  • Eye Infections, Fungal / diagnosis
  • Eye Infections, Fungal / drug therapy
  • Eye Infections, Fungal / etiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Keratoconus / surgery
  • Surgical Wound Infection / diagnosis
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / etiology*
  • Visual Acuity


  • Antifungal Agents