Toward biotechnological production of adipic acid and precursors from biorenewables

Abstract

Adipic acid is the most important commercial aliphatic dicarboxylic acid in the chemical industry and is primarily used for the production of nylon-6,6 polyamide. The current adipic acid market volume is about 2.6 million tons/y and the average annual demand growth rate forecast to stay at 3-3.5% worldwide. Hitherto, the industrial production of adipic acid is carried out by petroleum-based chemo-catalytic processes from non-renewable fossil fuels. However, in the past years, efforts were made to find alternative routes for adipic acid production from renewable carbon sources by biotechnological processes. Here we review the approaches and the progress made toward bio-based production of adipic acid.

Keywords: 2-Oxoadipic acid; Benzoate; Cis, cis-muconic acid; Escherichia coli; Glucaric acid; Pseudomonas sp..