Pregnancy outcome in anti-N-methyl-D-aspartate receptor encephalitis

Obstet Gynecol. 2012 Aug;120(2 Pt 2):480-483. doi: 10.1097/AOG.0b013e31825935d4.


Background: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder resulting in neurologic and psychiatric symptoms. Treatment is challenging in pregnancy, because little data exist to guide management.

Case: A 24-year-old woman with a known diagnosis of anti-NMDA receptor encephalitis using intravenous immunoglobulin therapy became pregnant. Her pregnancy was uncomplicated with no relapses. She delivered at 35 4/7 weeks of gestation after having preterm premature rupture of membranes. She had a relapse of symptoms after delivery.

Conclusion: This patient with anti-NMDA receptor encephalitis had an uneventful pregnancy with overall good outcome; however, she experienced relapse soon after delivery. This disease may mimic other autoimmune diseases, with improvement during pregnancy and risk for relapse postpartum.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / diagnosis*
  • Autoimmune Diseases / diagnosis*
  • Female
  • Fetal Membranes, Premature Rupture / etiology
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage
  • Infant, Newborn
  • Infant, Premature
  • Pregnancy
  • Pregnancy Complications*
  • Pregnancy Outcome*
  • Recurrence
  • Young Adult


  • Immunoglobulins, Intravenous