Long-term side effects and cosmetic outcome in a pool of breast cancer patients treated with intraoperative radiotherapy with electrons as sole treatment

Tumori. 2012 May-Jun;98(3):324-30. doi: 10.1177/030089161209800308.


Aims: To evaluate late toxicity and cosmetic outcome after intraoperative radiotherapy using electrons (ELIOT) as sole treatment modality in early breast cancer patients.

Methods: A total of 119 patients selected randomly among 1200 cases was analyzed. Late toxicities were documented using the LENT-SOMA scoring system, cosmesis was evaluated with the Harvard scale, and a numeric rating scale was used to assess symptoms.

Results: After a median follow-up of 71 months, grade II fibrosis was observed in 38 patients (31.9%) and grade III fibrosis in 7 patients (5.9%). Postoperative complications (12.6%) did not correlate with late toxicity. Physicians and patients scored cosmesis as excellent or good in 84% and 77.3% of the cases, respectively. Patient satisfaction was higher than 90%.

Conclusions: In the study, ELIOT gives low and acceptable long-term toxicity. A longer follow-up and a larger number of patients are needed to confirm these promising results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Beauty*
  • Biomarkers, Tumor / analysis
  • Breast Neoplasms / pathology
  • Breast Neoplasms / radiotherapy*
  • Breast Neoplasms / surgery*
  • Carcinoma, Ductal, Breast / radiotherapy
  • Carcinoma, Ductal, Breast / surgery
  • Carcinoma, Lobular / radiotherapy
  • Carcinoma, Lobular / surgery
  • Electrons / adverse effects
  • Electrons / therapeutic use*
  • Female
  • Fibrosis / etiology
  • Follow-Up Studies
  • Humans
  • Intraoperative Period
  • Italy
  • Mastectomy, Segmental*
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Patient Satisfaction / statistics & numerical data
  • Radiotherapy Dosage
  • Radiotherapy, Adjuvant / adverse effects
  • Radiotherapy, Adjuvant / methods
  • Treatment Outcome


  • Biomarkers, Tumor