Comparison of inhaled nitric oxide and aerosolized iloprost in pulmonary hypertension in children with congenital heart surgery

Cardiol J. 2012;19(4):387-94. doi: 10.5603/cj.2012.0070.


Background: Pulmonary arterial hypertension is of importance in congenital cardiac surgery as being a significant cause of morbidity and mortality. Although therapy options are limited, inhaled nitric oxide (NO) is used as a standard therapy. The present study aimed to compare inhaled NO and aerosolized iloprost in children with secondary pulmonary hypertension who underwent congenital cardiac surgery.

Methods: Sixteen children included in the study were randomized into either inhaled NO or aerosolized iloprost group. For both groups, the observation period terminated at 72 h after cardiopulmonary bypass.

Results: There was no significant difference between the groups in terms of mean age, weight, cross clamp time, pump time, and extubation time. No significant change was observed in the arterial tension and central venous pressure of both groups before the operation, 30 min after the pump, 45 min after the pump, and after extubation, whereas an increase was observed in the heart rate and cardiac output, and a decrease was observed in the pulmonary artery pressure. The mean values at the above-mentioned time points showed no difference between the groups. No serious adverse event and mortality was detected.

Conclusions: Both inhaled NO and aerosolized iloprost were found to be effective and comparable in the management of pulmonary hypertension.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Inhalation
  • Aerosols
  • Antihypertensive Agents / administration & dosage*
  • Cardiac Surgical Procedures*
  • Child
  • Child, Preschool
  • Familial Primary Pulmonary Hypertension
  • Heart Defects, Congenital / complications
  • Heart Defects, Congenital / physiopathology
  • Heart Defects, Congenital / surgery*
  • Hemodynamics / drug effects
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / etiology
  • Hypertension, Pulmonary / physiopathology
  • Iloprost / administration & dosage*
  • Infant
  • Infant, Newborn
  • Nitric Oxide / administration & dosage*
  • Time Factors
  • Treatment Outcome
  • Turkey
  • Vasodilator Agents / administration & dosage*


  • Aerosols
  • Antihypertensive Agents
  • Vasodilator Agents
  • Nitric Oxide
  • Iloprost