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. 2012 Aug;199(2):458-64.
doi: 10.2214/AJR.10.6096.

Triple Receptor-Negative Breast Cancer: Imaging and Clinical Characteristics

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Free PMC article

Triple Receptor-Negative Breast Cancer: Imaging and Clinical Characteristics

Kristin M Krizmanich-Conniff et al. AJR Am J Roentgenol. .
Free PMC article

Abstract

Objective: The objective of our study was to retrospectively evaluate the imaging findings of patients with breast cancer negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)-so-called "triple receptor-negative cancer"-and to compare the mammographic findings and clinical characteristics of triple receptor-negative cancer with non-triple receptor-negative cancers (i.e., ER-positive, PR-positive, or HER2-positive or two of the three markers positive).

Conclusion: Triple receptor-negative cancer was most commonly an irregular noncalcified mass with ill-defined or spiculated margins on mammography and a hypoechoic or complex mass with an irregular shape and noncircumscribed margins on ultrasound. Most triple receptor-negative cancers were discovered on physical examination. Compared with non-triple receptor-negative cancers, triple receptor-negative cancers were found in younger women and were a higher pathologic grade.

Figures

Figure 1
Figure 1
Figure 1a. Post-menopausal female presenting with a palpable mass, found to be TN breast cancer. Mammography demonstrates an irregular mass with spiculated margins without calcifications (arrows). Figure 1b. (Same TN patient as in Fig. 1a.) Ultrasound demonsrates an irregular, hypoechoic mass with spiculated margins (arrows).
Figure 2
Figure 2
Mammography in a TN case demonstrates an irregular retroareolar mass with ill-defined margins (arrows).
Figure 3
Figure 3
Mammography in a TN case demonstrates a round mass with microlobulated margins (arrows).
Figure 4
Figure 4
Ultrasound in a TN case demonstrates a round mass with microlobulated margins (arrows) and a complex echo pattern.
Figure 5
Figure 5
Ultrasound in a TN case demonstrates an irregular mass with ill-defined margins and a complex echo pattern.

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